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Non-IgE Allergy [was: bowels are the culprit] ?

Question:
the reason cp/cpps very seldom responds to conventional treatment is that drs are always treating the prostate when very few of us have prostate problems,bacterial infections,or inflammation of the prostate. why do you think broccoli juice helps a lot of us?it isn,t doing anything for the prostate,it is soothing the bowels. why are so many of us helped by laying off wheat or changing our diets. it causes changes in the bowels and eases the symptoms. i can go 12 hrs without food and my pain always gets better.i can 24 hrs without food and my pain is almost gone.it has got to be a problem with the bowels causing deferred pain into the testicles,rectum, and lower back. why do so many of us feel pretty good in the morning only to have the pain return later in the day.because we have been all night without food and the pain starts easing off,only to start eating again after we rise and wait for the pain to return.why do herbs and supplements help a lot of us. they are not doing any thing for the prostate.think about where they end up in the bowels. again they are soothing the bowels and easing the pain. i think the reason abx,s help some us is because they temporarily heal the bowel problem.only to have the problem return after the abx's have run their course. i think if dr's started treating the bowel problem we might have something to look forward too.


Answer:
This is a very good point , and I can only recall one other person making this point on this group in the past. It certainly was true in my case. Not eating anything would lead to a rapid improvement in all symptoms, not only in the prostate but also the tiredness, depression, muscle pain, sinusitis, bowel disturbance and numerous other niggling symptoms. Absolutely, this has nothing to do with bacteria. It has to do with (my guess) an immune system gone awry, mast cells proliferating and degranulating
(perhaps), atopy (perhaps) -- all caused by a genetic predisposition coupled with, who knows, an overclean environment (see recent theories on asthma etiology). Altogether not something urologists should be studying or treating, you may think.
***I'd love to buy in to the allergy theory, but I haven't come across any experimental evidence to support it. The cytokines most commonly found to be elevated in the prostatic fluid of CPPS patients are the Th1 Cytokines, TNF-alpha and IL-1 Beta. This is the opposite of what would be expected for an allergic reaction, where a Th2 cytokine profile would dominate. I'm not suggesting that an allergy is definitely not involved in some cases; I just haven't come across any evidence for it. By the way, fasting has endocrine effects, which may be more relevant to the improvements you are describing than the elimination of potential food antigens. Aha! Yes, BUT we need to consider the different cytokine profile of non-IgE food allergy. What about, for instance, Type IV hypersensitivity, often linked to Crohn's in research? More importantly, what about Type III (serum sickness), where there is a substantial production of antibodies as a reaction to antigens in the blood (the two link up to form "immune complexes", which drift around in the blood, tending to settle in poorly perfused areas and causing chronic inflammation)? Type II hypersensitivity underlies autoimmune diseases like SLE. It is also possible for food particles to enter the blood stream (leaky gut syndrome, recently endorsed by research) and form these same immune complexes. The subject is a vast and complex one, and I am quite sure, from personal experience (and several experiments), that it is an important, maybe key, part of the mystery surrounding CP/CPPS. Once again, let me recommend this book: http://www.amazon.com/exec/obidos/ASIN/0892818751/cpcppsnetwork-20 Sitting or perineal pain seems to be most common. The prostate is constantly emptying its secretions into the urethra. There is no doubt in my mind that my prostate is not functioning right and these secretions could be very irritative to the urethra and entire area. The happiest men I know have had their prostate removed and are not taking pain pills. Again many of us experience urethral pain after ejaculation. Burning ejacs also point to this constant irritation. My patience is wearing thin. Sure keep your prostate and take your pain pills till you die if they dont destroy your kidneys and liver first. Let us hear from the men who have had their prostates removed who are painfree and happy.



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